(Source: cnoeviil, via freedumbxfighter)

(Source: fer1972, via downsincedawn)

bustatit:

blvckgoldenn:

Aaliyah and her brother Rashad

Omg

bustatit:

blvckgoldenn:

Aaliyah and her brother Rashad

Omg

(Source: mustafasmith, via they0ungdreamer)

(Source: minvs, via easyriderr)

neurosciencestuff:

Study IDs new cause of brain bleeding immediately after stroke
By discovering a new mechanism that allows blood to enter the brain immediately after a stroke, researchers at UC Irvine and the Salk Institute have opened the door to new therapies that may limit or prevent stroke-induced brain damage.
A complex and devastating neurological condition, stroke is the fourth-leading cause of death and primary reason for disability in the U.S. The blood-brain barrier is severely damaged in a stroke and lets blood-borne material into the brain, causing the permanent deficits in movement and cognition seen in stroke patients.
Dritan Agalliu, assistant professor of developmental & cell biology at UC Irvine, and Axel Nimmerjahn of the Salk Institute for Biological Studies developed a novel transgenic mouse strain in which they use a fluorescent tag to see the tight, barrier-forming junctions between the cells that make up blood vessels in the central nervous system. This allows them to perceive dynamic changes in the barrier during and after strokes in living animals.
While observing that barrier function is rapidly impaired after a stroke (within six hours), they unexpectedly found that this early barrier failure is not due to the breakdown of tight junctions between blood vessel cells, as had previously been suspected. In fact, junction deterioration did not occur until two days after the event.
Instead, the scientists reported dramatic increases in carrier proteins called serum albumin flowing directly into brain tissue. These proteins travel through the cells composing blood vessels – endothelial cells – via a specialized transport system that normally operates only in non-brain vessels or immature vessels within the central nervous system. The researchers’ work indicates that this transport system underlies the initial failure of the barrier, permitting entry of blood material into the brain immediately after a stroke (within six hours).
“These findings suggest new therapeutic directions aimed at regulating flow through endothelial cells in the barrier after a stroke occurs,” Agalliu said, “and any such therapies have the potential to reduce or prevent stroke-induced damage in the brain.”
His team is currently using genetic techniques to block degradation of the tight junctions between endothelial cells in mice and examining the effect on stroke progression. Early post-stroke control of this specialized transport system identified by the Agalliu and Nimmerjahn labs may spur the discovery of imaging methods or biomarkers in humans to detect strokes as early as possible and thereby minimize damage.

neurosciencestuff:

Study IDs new cause of brain bleeding immediately after stroke

By discovering a new mechanism that allows blood to enter the brain immediately after a stroke, researchers at UC Irvine and the Salk Institute have opened the door to new therapies that may limit or prevent stroke-induced brain damage.

A complex and devastating neurological condition, stroke is the fourth-leading cause of death and primary reason for disability in the U.S. The blood-brain barrier is severely damaged in a stroke and lets blood-borne material into the brain, causing the permanent deficits in movement and cognition seen in stroke patients.

Dritan Agalliu, assistant professor of developmental & cell biology at UC Irvine, and Axel Nimmerjahn of the Salk Institute for Biological Studies developed a novel transgenic mouse strain in which they use a fluorescent tag to see the tight, barrier-forming junctions between the cells that make up blood vessels in the central nervous system. This allows them to perceive dynamic changes in the barrier during and after strokes in living animals.

While observing that barrier function is rapidly impaired after a stroke (within six hours), they unexpectedly found that this early barrier failure is not due to the breakdown of tight junctions between blood vessel cells, as had previously been suspected. In fact, junction deterioration did not occur until two days after the event.

Instead, the scientists reported dramatic increases in carrier proteins called serum albumin flowing directly into brain tissue. These proteins travel through the cells composing blood vessels – endothelial cells – via a specialized transport system that normally operates only in non-brain vessels or immature vessels within the central nervous system. The researchers’ work indicates that this transport system underlies the initial failure of the barrier, permitting entry of blood material into the brain immediately after a stroke (within six hours).

“These findings suggest new therapeutic directions aimed at regulating flow through endothelial cells in the barrier after a stroke occurs,” Agalliu said, “and any such therapies have the potential to reduce or prevent stroke-induced damage in the brain.”

His team is currently using genetic techniques to block degradation of the tight junctions between endothelial cells in mice and examining the effect on stroke progression. Early post-stroke control of this specialized transport system identified by the Agalliu and Nimmerjahn labs may spur the discovery of imaging methods or biomarkers in humans to detect strokes as early as possible and thereby minimize damage.

(via itssvee)

(Source: itssveeagain)

anasaltukhaifi:

Umbrellas Street, Portugal.

anasaltukhaifi:

Umbrellas Street, Portugal.

(Source: jasmineberryful, via kushandjcrew)

lucafinotti:

ATTACK ART / fuuuckingyoung issue 4
Photographer: Luca Finotti
Art Directors: Luca Finotti e Paolo Zagoreo
Stylist: Paolo Zagoreo
Models: Alex Pierce @ Elite Models
Cristi Isofii @ Boom Models Agency
Gabriel Shinel @ Indipendent Agency
Lucas Kittel @ Urban Management
Marin @ Indipendent Agency
Martin @ 2Morrow Models
Patrick @ 2Morrow Models
Rowna @ 2Morrow Models
Vitan @ Indipendent Agency
Assistant photographer: Pietro Frizzi
Hair: Gabriele Trezzi @ Close-up Milano
Make up: Giorgia Pambianchi ATOMO MANAGEMENT
Printed scarves & PVC trousers by Saint Laurent

lucafinotti:

ATTACK ART / fuuuckingyoung issue 4

Photographer: Luca Finotti

Art Directors: Luca Finotti e Paolo Zagoreo

Stylist: Paolo Zagoreo

Models: 
Alex Pierce @ Elite Models

Cristi Isofii @ Boom Models Agency

Gabriel Shinel @ Indipendent Agency

Lucas Kittel @ Urban Management

Marin @ Indipendent Agency

Martin @ 2Morrow Models

Patrick @ 2Morrow Models

Rowna @ 2Morrow Models

Vitan @ Indipendent Agency

Assistant photographer: Pietro Frizzi

Hair: Gabriele Trezzi @ Close-up Milano

Make up: Giorgia Pambianchi ATOMO MANAGEMENT

Printed scarves & PVC trousers by Saint Laurent

(via kushandjcrew)

tyleroakley:

entropiaorganizada:

hookteeth:

… Y’see, now, y’see, I’m looking at this, thinking, squares fit together better than circles, so, say, if you wanted a box of donuts, a full box, you could probably fit more square donuts in than circle donuts if the circumference of the circle touched the each of the corners of the square donut.
So you might end up with more donuts.
But then I also think… Does the square or round donut have a greater donut volume? Is the number of donuts better than the entire donut mass as a whole?
Hrm.
HRM.

A round donut with radius R1 occupies the same space as a square donut with side 2R1. If the center circle of a round donut has a radius R2 and the hole of a square donut has a side 2R2, then the area of a round donut is πR12 - πr22. The area of a square donut would be then 4R12 - 4R22. This doesn’t say much, but in general and  throwing numbers, a full box of square donuts has more donut per donut than a full box of round donuts.The interesting thing is knowing exactly how much more donut per donut we have. Assuming first a small center hole (R2 = R1/4) and replacing in the proper expressions, we have a 27,6% more donut in the square one (Round: 15πR12/16 ≃ 2,94R12, square: 15R12/4 = 3,75R12). Now, assuming a large center hole (R2 = 3R1/4) we have a 27,7% more donut in the square one (Round: 7πR12/16 ≃ 1,37R12, square: 7R12/4 = 1,75R12). This tells us that, approximately, we’ll have a 27% bigger donut if it’s square than if it’s round.
tl;dr: Square donuts have a 27% more donut per donut in the same space as a round one.

Thank you donut side of Tumblr.

tyleroakley:

entropiaorganizada:

hookteeth:

… Y’see, now, y’see, I’m looking at this, thinking, squares fit together better than circles, so, say, if you wanted a box of donuts, a full box, you could probably fit more square donuts in than circle donuts if the circumference of the circle touched the each of the corners of the square donut.

So you might end up with more donuts.

But then I also think… Does the square or round donut have a greater donut volume? Is the number of donuts better than the entire donut mass as a whole?

Hrm.

HRM.

A round donut with radius R1 occupies the same space as a square donut with side 2R1. If the center circle of a round donut has a radius R2 and the hole of a square donut has a side 2R2, then the area of a round donut is πR12 - πr22. The area of a square donut would be then 4R12 - 4R22. This doesn’t say much, but in general and  throwing numbers, a full box of square donuts has more donut per donut than a full box of round donuts.

The interesting thing is knowing exactly how much more donut per donut we have. Assuming first a small center hole (
R2 = R1/4) and replacing in the proper expressions, we have a 27,6% more donut in the square one (Round: 15πR12/16 ≃ 2,94R12, square: 15R12/4 = 3,75R12). Now, assuming a large center hole (R2 = 3R1/4) we have a 27,7% more donut in the square one (Round: 7πR12/16 ≃ 1,37R12, square: 7R12/4 = 1,75R12). This tells us that, approximately, we’ll have a 27% bigger donut if it’s square than if it’s round.


tl;dr: Square donuts have a 27% more donut per donut in the same space as a round one.

Thank you donut side of Tumblr.

(Source: nimstrz, via qrace)

#WCW

Hats off to all my boss bitches being a REAL model not a ROLE model, struggling to be better… Making moves in silence. Be the REAL model that these young people need. Let them know they don’t have to play a fake ass ROLE to make it in life. Them looks ain’t gonna get you everywhere boo. Work hard, juggle those work/school schedules. Your time will come soon enough. Queen.

REMEMBER WHEN JAY RANDOMLY DID A TWITTER Q&A LMAO.

(Source: life-of-beyonce, via fashionjunki)

insidemycrazyarms:

love-tastes-like-lemon-juice:

opium-eyes:

planetaryeuphoria:

danielleraeee:

Woodstock, 1969….. oh my god…..

The things i would do to be there

the things I would do to be able to experience all of this

The things I would DO THERE

I wish the hills still looked that way.

(Source: jimmy-page-is-my-love, via kushandcake)