Targeted Immune System Booster Removes Toxic Proteins in Mouse Model of Alzheimer’s Disease
Read the full article at Targeted Immune System Booster Removes Toxic Proteins in Mouse Model of Alzheimer’s Disease at NeuroscienceNews.com.
Alzheimer’s disease experts at NYU Langone Medical Center and elsewhere are reporting success in specifically harnessing a mouse’s immune system to attack and remove the buildup of toxic proteins in the brain that are markers of the deadly neurodegenerative disease.
The research is in Acta Neuropathologica Communications. (full access paywall)
Research: “Amyloid beta and Tau Alzheimer’s Disease Related Pathology is reduced by Toll-like Receptor 9 Stimulation” by Henrieta Scholtzova, Peter Chianchiano, Jason Pan, Yanjie Sun, Fernando Goni, Pankaj D Mehta and Thomas Wisniewski in Acta Neuropathologica Communications. doi:10.1186/s40478-014-0101-2 (http://www.actaneurocomms.org/content/pdf/s40478-014-0101-2.pdf)
Image: The research team calls their findings the first positive results for targeted stimulation of the natural, or innate immune system to both prevent the onset of Alzheimer’s disease in animals bred to develop dementia, and to reverse its symptoms after the disease has already set in. The image is for illustrative purposes only and shows shows a health brain slice and a brain slice taken from a person with Alzheimer’s disease. Credit NIH.